MIRA-HOPE team combines the use of optical microscopy and high-definition sampling techniques to: 1) significantly increase the resolution with which we can detect and characterize lifetime events in bones and dental tissues, 2) explore the potential of different stable isotope systems as markers of dietary practices, geographic origins and changes in climatic variables, and 3) enable the full morphological and biochemical characterization of microbotanicals to improve taxonomic identification. In addition, we develop 3D models of excavations, artifacts and human remains for paleoanthropological, archaeological and bioarchaeological studies. Innovative cross-fertilization of these different lines of evidence, and their application in examining human–environment interactions, represents the most important contribution of the team to the field of bioanthropology.